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| First Round Draft Pick History |
| 1 | 11 | 11 | 2021 | Annual Draft | P | Josh | Fleming | MLB |
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| Complete Draft History |
| 1 | 11 | 11 | 2021 | Annual Draft | P | Josh | Fleming | MLB |
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| 2 | 11 | 31 | 2021 | Annual Draft | P | Spencer | Howard | MLB |
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| 3 | 11 | 51 | 2021 | Annual Draft | P | Kyle | Zimmer | MLB |
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| 4 | 11 | 71 | 2021 | Annual Draft | C | Luis | Torrens | MLB |
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| 5 | 16 | 96 | 2021 | Annual Draft | OF+ | Darin | Ruf | MLB |
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| 6 | 11 | 111 | 2021 | Annual Draft | P | Tom | Hatch | MLB |
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| 7 | 11 | 131 | 2021 | Annual Draft | P | Daulton | Jefferies | MLB |
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| 8 | 6 | 146 | 2021 | Annual Draft | P | James | Kaprielian | MLB |
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| 9 | 11 | 171 | 2021 | Annual Draft | 3B+ | Vimael | Machin | MLB |
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| 10 | 11 | 191 | 2021 | Annual Draft | P | Jorge | Lopez | MLB |
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| 11 | 11 | 211 | 2021 | Annual Draft | OF | Daz | Cameron | MLB |
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| 12 | 11 | 231 | 2021 | Annual Draft | P | Wes | Benjamin | MLB |
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